Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
Identifieur interne : 009670 ( Main/Exploration ); précédent : 009669; suivant : 009671Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
Auteurs : Mattias Johansson [Suède] ; James D. Mckay [France, Australie] ; P R Stattin [Suède] ; Federico Canzian [France, Allemagne] ; Catherine Boillot [France] ; Fredrik Wiklund [Suède] ; Hans-Olov Adami [Suède, États-Unis] ; Katarina B Lter [Suède] ; Henrik Grönberg [Suède] ; Rudolf Kaaks [France, Allemagne]Source :
- International journal of cancer [ 0020-7136 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
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Abstract
Insulin-like growth factor-I (IGF1) stimulates cell proliferation, decreases apoptosis, and has been implicated in cancer development. Epidemiological studies have shown elevated levels of circulating IGF1 to be associated with increased risk of prostate cancer. To what extent genetic variation in the IGF1 gene is related to prostate cancer risk is largely unknown. We performed a comprehensive haplotype tagging (HT) assessment of single nucleotide polymorphisms (SNPs) representing the common haplotype variation in the IGF1 gene. We genotyped 10 SNPs (9 haplotype tagging SNPs (htSNPs)) within Cancer Prostate in Sweden (CAPS), a case-control study of 2,863 cases and 1,737 controls, in order to investigate if genetic variation in the IGF1 gene is associated with prostate cancer risk. Three haplotype blocks were identified across the IGF1 gene and 9 SNPs were selected as haplotype tagging SNPs. Common haplotypes in the block covering the 3' region of the IGF1 gene showed significant global association with prostate cancer risk (p = 0.004), with one particular haplotype giving an odds ratio of 1.46 (95% CI = 1.15-1.84, p = 0.002). This haplotype had a prevalence of 5% in the study population. Our results indicate that common variation in the IGF1 gene, particularly in the 3' region, may affect prostate cancer risk. Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding.
Affiliations:
- Allemagne, Australie, France, Suède, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, District de Karlsruhe, Massachusetts, Rhône-Alpes, Svealand
- Cambridge (Massachusetts), Heidelberg, Lyon, Stockholm
- Université Harvard
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level="a">Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer</title><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University Hospital</s1><s2>Ume?</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ume?</wicri:noRegion></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Menzies Research Institute</s1><s2>Hohart, Tasmania</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Menzies Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University Hospital</s1><s2>Ume?</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ume?</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Genomic Epidemiology Group, German Cancer Institute (DKFZ)</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Boillot, Catherine" sort="Boillot, Catherine" uniqKey="Boillot C" first="Catherine" last="Boillot">Catherine Boillot</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Epidemiology, Harvard University</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="B Lter, Katarina" sort="B Lter, Katarina" uniqKey="B Lter K" first="Katarina" last="B Lter">Katarina B Lter</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>International Agency for Research on Cancer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of cancer</title><title level="j" type="abbreviated">Int. j. cancer</title><idno type="ISSN">0020-7136</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cancer</title><title level="j" type="abbreviated">Int. j. cancer</title><idno type="ISSN">0020-7136</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Case control study</term><term>Epidemiology</term><term>Gene</term><term>Genetic variability</term><term>Genotype</term><term>Haplotype</term><term>Human</term><term>Insulin like growth factor 1</term><term>Nephrology</term><term>Prostate cancer</term><term>Risk factor</term><term>Single nucleotide polymorphism</term><term>Sweden</term><term>Urology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer prostate</term><term>Variabilité génétique</term><term>Gène</term><term>Facteur croissance IGF1</term><term>Génotype</term><term>Facteur risque</term><term>Epidémiologie</term><term>Polymorphisme mononucléotide</term><term>Haplotype</term><term>Cancérologie</term><term>Etude cas témoin</term><term>Suède</term><term>Urologie</term><term>Homme</term><term>Néphrologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin-like growth factor-I (IGF1) stimulates cell proliferation, decreases apoptosis, and has been implicated in cancer development. Epidemiological studies have shown elevated levels of circulating IGF1 to be associated with increased risk of prostate cancer. To what extent genetic variation in the IGF1 gene is related to prostate cancer risk is largely unknown. We performed a comprehensive haplotype tagging (HT) assessment of single nucleotide polymorphisms (SNPs) representing the common haplotype variation in the IGF1 gene. We genotyped 10 SNPs (9 haplotype tagging SNPs (htSNPs)) within Cancer Prostate in Sweden (CAPS), a case-control study of 2,863 cases and 1,737 controls, in order to investigate if genetic variation in the IGF1 gene is associated with prostate cancer risk. Three haplotype blocks were identified across the IGF1 gene and 9 SNPs were selected as haplotype tagging SNPs. Common haplotypes in the block covering the 3' region of the IGF1 gene showed significant global association with prostate cancer risk (p = 0.004), with one particular haplotype giving an odds ratio of 1.46 (95% CI = 1.15-1.84, p = 0.002). This haplotype had a prevalence of 5% in the study population. Our results indicate that common variation in the IGF1 gene, particularly in the 3' region, may affect prostate cancer risk. Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Suède</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Massachusetts</li><li>Rhône-Alpes</li><li>Svealand</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Heidelberg</li><li>Lyon</li><li>Stockholm</li></settlement><orgName><li>Université Harvard</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name></noRegion><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name><name sortKey="B Lter, Katarina" sort="B Lter, Katarina" uniqKey="B Lter K" first="Katarina" last="B Lter">Katarina B Lter</name><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name></region><name sortKey="Boillot, Catherine" sort="Boillot, Catherine" uniqKey="Boillot C" first="Catherine" last="Boillot">Catherine Boillot</name><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></country><country name="Australie"><noRegion><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name></region><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
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